Association with beta 2microglobulin is generally required for the transport of class i heavy chains. Increased amounts of beta2microglobulin are excreted in several renal disorders, e. Definition beta 2 microglobulin is a protein found on the surface of many cells. It is recommended that each laboratory establish its own normal and pathological ranges of urine levels. Lee biosolutions is the leading producer and supplier of recombinant beta2 microglobulin b2m for use in medical research and manufacturing of clinical diagnostic assays. May 03, 2020 a protein found on the surface of many cells, including white blood cells. We use cookies to give you the best possible experience on our website. Its concentration increases in various pathologies. The information on this page was automatically extracted from online scientific databases. Beta 2 microglobulin b2m human b2m native antigen prospec.
Pdf there is currently an unmet need for better biomarkers across the spectrum of renal diseases. When impaired, serum levels rise in inverse ratio to glomerular filtration rate. May 07, 2020 beta 2 microglobulin b2m is a naturally occurring protein in the human body. Using immunoturbidimetry, we examined concentrations of beta2 microglobulin in cerebrospinal fluid in a large group of 6274 patients with defined.
For a blood test, a health care professional will take a blood sample from a vein in your arm, using a small needle. Also valuable in assessing for chronic severe inflammatory and renal diseases. The present study was designed to determine the normal range of serum beta 2 microglobulin sb 2 m levels among healthy volunteers in brazil. Beta2microglobulin b2m is a protein that is found on the surface of almost all cells in the body and is shed by cells into the blood, particularly by b lymphocytes and tumour cells.
View details of cost of test, pre test information and. Systemic lupus erythematosus activity and beta two. Beta2microglobulin normally passes through the glomerulus into the proximal tubule where much of it is reabsorbed. Beta 2 microglobulin b2m is a protein that is found on the surface of almost all cells in the body and is shed by cells into the blood, particularly by b lymphocytes and tumour cells. The randox beta2 microglobulin reagent can comfortably detect levels outside of this range with a measuring range of 0. Beta2microglobulin, blood and urine definition of beta2. Beta2microglobulin levels in the blood may suggest kidney disease, glomeruli dysfunction, renal tubule or disease, or dialysisrelated amyloidosis. Serum beta 2 microglobulin, an endogenous marker for renal function, has been shown to be an independent predictor of mortality in older adults.
Although these studies used different cutoff values 2. Introduction human beta2 microglobulin b2mg is an 11. This protein is routinely shed by cells into the blood and is present in most body fluids, with highest levels in the blood, generally lower levels in spinal fluid, and trace levels in urine in the kidneys, b2m passes through blood. The b2m test can be used as a tumor marker for some people with blood cell cancers multiple myeloma, lymphoma to give information about their likely prognosis. Recombinant human beta 2microglobulin protein h00000567. Beta2 microglobulin is a lowmolecularweight protein that forms the heavy chains component of class i histocompatibility hla. This gene encodes a serum protein found in association with the major histocompatibility complex mhc class i heavy chain on the surface of nearly all nucleated cells. Levels of beta 2 microglobulin have a prognostic relevance for patients with myelodysplastic syndrome with regard to survival and the risk. Beta2microglobulin beta 2 m is a small membrane protein 11,800 dalton associated with the heavy chains of class i major histocompatibility complex proteins and is, therefore, on the surface of all nucleated cells. Beta2 microglobulin kidney disease lab tests online. Beta2 microglobulin b2m is a protein that is found on the surface of nucleated cells contain a nucleus and functions as part of the human immune system. Beta2microglobulin general information lab order codes. It associates with 3 alphachains, stabilizing the binding groove. After the needle is inserted, a small amount of blood will be collected into a test.
Like many other markers for diseases, the beta 2 micro globulin does. Beta2microglobulin as a diagnostic marker in cerebrospinal. Beta 2 microglobulin deficient mice as a model for hemachromatosis. Specimen serum 1 ml collected in a red or redgraytop tube or 5 ml urine from a timed collection in a clean. Beta2 microglobulin b2m levels increase during infection with some viruses, including hiv.
In serum or plasma samples, the reference range is 03 gml. Beta2 microglobulin is involved in the composition of mhc class 1 molecules. The problem with cancer is that the body does not recognize these malignant cells as being foreign. B2m also has been used to evaluate kidney function following a kidney.
By continuing to use this site you consent to the use of cookies on your device as described in our cookie policy unless you have disabled them. Serum beta2 microglobulin, an endogenous marker for renal function, has been shown to be an independent predictor of mortality in older adults. Beta2 microglobulin levels in hemodialysis patients. Seric level of beta 2microglobulin in patients with active pulmonary. Dr lal pathlabs offers home collection booking service for beta 2 microglobulin serum to test for disorders of kidney. Exogenously applied rculosis esxa or esxaesxb or esxa expressed in host binds b2m and decreases its export to the cell surface total protein levels do not change, probably leading to defects in class i antigen presentation pubmed. Circulating beta2 microglobulin and risk of cancer. Serum levels are therefore an index of glomerular function. The cumulative incidence of renal tubular dysfunction reach 90% by 6 years of deferasirox therapy, with a third of the patients developing dysfunction at 11 months in a retrospective. Samples can be stored for 1 week at 2 8c or for up to one year at. We evaluated the relevance of beta 2 microglobulin b2m plasma concentration in 109 patients with myelodysplastic syndrome mds from the duesseldorf registry. Beta 2 microglobulin preparation, procedure, cost, normal. Beta2 microglobulin is a protein that is found on the surface of almost all cells nucleated cells in your body and functions as part of the human immune system. This protein further functions to present antigens to cytotoxic t lymphocytes that.
Pdf beta2microglobulindeficient mice as a model for. Levin beta2 microglobulin is the most widely studied lowmolecularweight protein in endstage renal disease. Beta 2 micro globulin level is a marker for tumors, disease, and kidney function problems. A protein found on the surface of many cells, including white blood cells. This feature of the beta 2 micro globulin makes it useful in the diagnosis of various types of diseases. Involved in the presentation of peptide antigens to the immune system. The criteria for no significant interference is recovery within 10% of the initial value.
This structure allows all nucleated cells to expose selfantigens out of the cytoplasmic membrane, enabling the immune system of the individual to recognize the cell as self. A local inflammatory reaction to beta 2 microglobulin beta 2 m amyloid deposits by monocytesmacrophages is a characteristic histologic feature of dialysisrelated amyloidosis dra. Useful for prognosis evaluation of multiple myeloma and for evaluation. The other 3 include alpha 1, alpha 2, and alpha 3 see second image below. Beta 2 microglobulin is the most widely studied lowmolecularweight protein in endstage renal disease. Beta2 microglobulin is the most widely studied lowmolecularweight protein in endstage renal disease. Beta 2 microglobulin concentration reported in mcgml. Background dialysisrelated destructive spondyloarthropathy caused by beta 2 microglobulin. Common use to assist in diagnosing malignancy such as lymphoma, leukemia, or multiple myeloma. Pdf rediscovering beta2 microglobulin as a biomarker across. This protein is routinely shed by cells into the blood and is present in most body fluids, with highest levels in the blood, generally lower levels in spinal fluid, and trace levels in urine.
Systemic lupus erythematosus sle is an autoimmune disease with periods of flares and remissions. Sep 05, 2014 the reference range of beta 2 microglobulin in urine samples is 00. Despite its potential role as a convenient and noninvasive prognostic indicator in malignant lymphomas, the influence of serum. Beta 2 microglobulin b2m is a protein that is found on the surface of nucleated cells contain a nucleus and functions as part of the human immune system. Apr 14, 2010 beta 2 micro globulin is a component molecule of the cells in the human body. Apr 28, 2020 component of the class i major histocompatibility complex mhc. It migrates in beta 2 region on electrophoresis and has a molecular weight of 11. Beta 2 microglobulin serum online booking, disorders of. Using immunoturbidimetry, we examined concentrations of beta2microglobulin in cerebrospinal fluid in a large group of 6274 patients with defined. A beta 2 microglobulin test is usually a blood test, but may also be given as a 24hour urine test, or as a cerebrospinal fluid csf analysis. Beta2 microglobulin b2m is a naturally occurring protein in the human body. Interpretation depends on the specific clinical indication and context. Beta 2 microglobulin is not diagnostic of a given disease but is usually an indicator of disease severity, e.
It is safe to assume that a patient with a high level of beta 2 micro globulin is likely to have a low chance of surviving a cancer because this high level indicates that the cancer is both strong and has spread around the body or the organ that is affected. Beta2 microglobulina marcador tumoral lab tests onlinees. Beta 2 microglobulin normally passes through the glomerulus into the proximal tubule where much of it is reabsorbed. Elevated urine beta2 microglobulin, low serum calcium, phosphate, and potassium were identified in 100% of patients n 18, most occurring within 100 months. M is a small globular peptide with a molecular weight of 11800 da. Association with beta 2 microglobulin is generally required for the transport of class i heavy chains from the endoplasmic reticulum to the cell surface. It is the small subunit of the mhc class i molecule. It is present in most body fluids and its level rises with conditions that increase cell production andor destruction, or that activate the immune system. Beta 2 microglobulin b2m is a protein that is found on the surface of almost all cells in the body and is shed by cells into the blood, particularly by b lymphocytes and tumor cells.
Beta2 microglobulin b2m is a protein that is found on the surface of almost all cells in the body and is shed by cells into the blood, particularly by b lymphocytes and tumor cells. This test measures b2m in the blood, urine, or rarely in. Guy sherwood the purpose of the bodys immune system is not only to recognize foreign antigens but also to be able to determine between self and not self. Feb 20, 2016 r egulation and m odulation of b eta 2 m icroglobulin. A local inflammatory reaction to beta2microglobulin beta2m amyloid deposits by monocytesmacrophages is a characteristic histologic feature of dialysisrelated amyloidosis dra. Sep 25, 2014 beta2 microglobulin is synthesized in all nucleated cells and forms the light chain subunit of the major histocompatibility complex class i antigen. Beta2 microglobulin an overview sciencedirect topics. It is homologous to ch 3 domain of human immunoglobulin. Beta 2 microglobulin is an 11 kda protein associated with the outer membrane of many cells including lymphocytes. Its levels tend to be elevated when a person is suffering from a particular type of cancer.
A study conducted in china that included patients with nasal enktl demonstrated that baseline serum b2m is an independent prognostic factor for pfs and os, and this. Evaluation of renal tubular toxicity, immune disorders, and lymphoid malignancies. Beta 2 microglobulin is a molecule that exists on nearly all cells that have a nucleus and to that extent is not a cause of worry. It is known to cause dialysisrelated amyloidosis dra, by virtue of its retention when. The implication and significance of beta 2 microglobulin. Levels of beta 2 microglobulin have a prognostic relevance. Increased values in cerebrospinal fluid csf are ascribed to an activation of immune system. The identification of the beta 2microglobulin binding antigen encoded by the human cd1d gene. It is identical to the light chain of the major histocompatibility complex mhc antigen hla 5. The small size allows beta 2 m to pass through the glomerular membrane, but it is almost completely reabsorbed in the proximal tubules.
Testing is done primarily when evaluating a person for certain kinds of cancer affecting white blood cells including chronic lymphocytic leukemia, nonhodgkins lymphoma, and multiple myeloma or kidney disease. Certain characteristics of b2m make it suitable for detecting tumor cells, especially in blood and kidney cells. The characteristics of b2m make it useful as a tumor marker for some blood cell cancers, for detecting kidney damage, and for distinguishing between glomerular and tubular disorders of the kidney. Serum beta2microglobulin values among healthy brazilians. Levels of sb 2 m are elevated in human immunodeficiency virus hivinfected patients and have been shown to be the best predictor of hiv infection status and of some malignant disorders, especially multiple myeloma. It is known to cause dialysisrelated amyloidosis dra, by virtue of its retention when renal function fails. The cpt codes provided are based on ama guidelines and are for informational purposes.